EquiShure® is a time-released buffer targeting the hindgut. Research supports the use of a hindgut buffer in cases of high grain and high fructan intake. Up to 70% of the horse’s energy is derived from fermentation in the hindgut. The pH of the hindgut varies as bacterial populations increase and decrease in response to dietary modifications. An acidic shift, which can be caused by carbohydrate-rich meals, favors the growth of acid-loving bacteria, while other microbes die in the same conditions.